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FLASH GENE
Symbol COL6A6 contributors: mct - updated : 25-04-2013
HGNC name collagen, type VI, alpha 6
HGNC id
DNA
TYPE functioning gene
STRUCTURE 116.71 kb     36 Exon(s)
MAPPING cloned Y linked N status provisional
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
36 - 8475 248.3 2263 - 2011 21406227
EXPRESSION
Type widely
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Cardiovascularheart     Homo sapiensAdult
Digestiveliver     Homo sapiensAdult
Lymphoid/Immunespleen     Homo sapiensAdult
 thymus     Homo sapiensAdult
Respiratorylung     Homo sapiensAdult
Skin/Tegumentskin     Homo sapiensAdult
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Epithelialbarrier liningepidermis   Homo sapiensAdult
Muscularstriatumskeletal   Homo sapiensAdult
cells
SystemCellPubmedSpeciesStageRna symbol
Skin/Tegumentepithelial cell Homo sapiensAdult
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • a 336-AA triple helix flanked by seven N-terminal von Willebrand factor A-like domains
  • two C-terminal von Willebrand factor A-like domains
  • mono polymer heteromer , trimer
    HOMOLOGY
    Homologene
    FAMILY
    CATEGORY
    SUBCELLULAR LOCALIZATION extracellular
    basic FUNCTION
  • important basal lamina component involved in the regulation of epithelial cell behavior most notably as a regulator of epithelial cell-fibronectin interactions
  • appears implicated in extracellular matrix remodeling during muscle fibrosis
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • heterotrimer composed of three alpha chains (alpha1, alpha2, alpha3) widely expressed throughout various interstitial matrices
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS