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FLASH GENE
Symbol ZNF692 contributors: mct - updated : 05-11-2012
HGNC name zinc finger protein 692
HGNC id 26049
DNA
TYPE functioning gene
STRUCTURE 9.11 kb     11 Exon(s)
regulatory sequence Promoter
text structure
  • possible transcriptional regulatory elements in the gene promoter, which may be involved in its regulation
  • MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    11 - 1760 - 474 - 2006 17097062
    12 - 1992 - 519 - 2006 17097062
    12 - 2208 - 524 - 2006 17097062
    EXPRESSION
    Type
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestiveliver   highly Mus musculus
    Nervousbrain   highly Mus musculus
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
    HOMOLOGY
    Homologene
    FAMILY
    CATEGORY transcription factor
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,nucleus
    basic FUNCTION
  • represses gene expression of the phosphoenolpyruvate carboxykinase (PCK2), a key enzyme of gluconeogenesis
  • novel key modulator of PCK2 gene expression regulated by AMPK
  • key modulator of hepatic glucose production regulated by AMPK
  • mediator of transcriptional repression of gluconeogenic genes in response to ATIC
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • binds to the promoter element of PCK2, a key enzyme of gluconeogenesis
  • cell & other
    REGULATION
    Phosphorylated by at Ser(470) by AMPK, and phosphorylation reduces its DNA-binding activity
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    SystemTypeDisorderPubmed
    diabete  
    combination of the diabetes therapies, pharmacological or nutraceutical induction of ZNF692 gene expression would be expected to reduce blood glucose levels in patients with diabetes
    ANIMAL & CELL MODELS
  • AREBP mice had lower blood glucose levels than WT mice after injection of Atic