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FLASH GENE
Symbol NEURL4 contributors: mct - updated : 20-10-2015
HGNC name neuralized homolog 4 (Drosophila)
HGNC id 34410
DNA
TYPE functioning gene
STRUCTURE 13.69 kb     29 Exon(s)
MAPPING cloned   linked   status
RNA
TRANSCRIPTS type
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
29 - 5211 - 1560 - -
29 - 5217 - 1562 - -
EXPRESSION
Type
   expressed in (based on citations)
organ(s)
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
HOMOLOGY
Homologene
FAMILY
CATEGORY structural protein
SUBCELLULAR LOCALIZATION     intracellular
intracellular,cytoplasm,cytoskeleton,microtubule,centrosome
text
  • centriole
  • HERC2 and NEURL4 localize to the centrosome
  • basic FUNCTION
  • promotes ubiquitylation of CCP110, thereby destabilizing this protein
  • counteracts accumulation of CCP110, thereby maintaining normal centriolar homeostasis and preventing formation of ectopic MTOCs (microtubular organizing centres)
  • is a protein that interacts with CCP110, a centrosomal protein that regulates centrosome duplication
  • centrosome-targeted NEURL4 was sufficient to restore ciliogenesis in cells with manipulated daughter centrioles
  • early during ciliogenesis, NEURL4 transiently associated with the mother centriole in a process that required mother-daughter centriole proximity
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • NEURL4-HERC2 complex participates in the ubiquitin-dependent regulation of centrosome architecture
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • HERC2 and the neuralized homologue NEURL4 are novel interaction partners of the centrosomal protein CCP110, and association between CCP110 and HERC2 depends on nonoverlapping regions of NEURL4
  • interacts with CCP110, a centrosomal protein that regulates centrosome duplication
  • several new UBE3A-interacting proteins, including HIF1AN, NEURL4, and mitogen-activated protein kinase 6 (MAPK6)
  • daughter centriole promotes ciliogenesis through NEURL4-dependent regulation of CP110 levels at the mother centriole
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS