basic FUNCTION
| exhibits a unique preference for phosphatidylinositol 5-phosphate (PI(5)P) as a substrate in vitro |
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indispensable role for PTPMT1 during development |
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crucial role in embryogenesis, revealing a mitochondrial metabolic stress-activated checkpoint in the control of ES cell differentiation |
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dephosphorylates phosphatidylglycerol phosphate (PGP), an essential intermediate of cardiolipin biosynthesis |
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T cells deficient for the cardiolipin-synthesizing enzyme PTPMT1 had reduced cardiolipin and responded poorly to antigen because basal cardiolipin levels were required for activation |
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required for embryonic cardiac cardiolipin biosynthesis to regulate mitochondrial morphogenesis and heart development |