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Symbol TCTN1 contributors: mct - updated : 14-12-2011
HGNC name tectonic family member 1
HGNC id 26113
DNA
TYPE
STRUCTURE 35.10 kb     15 Exon(s)
MAPPING cloned Y linked N status provisional
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
15 - 1969 - 483 - 2006 16357211
15 - 1983 - 573 - 2006 16357211
15 - 2040 - 592 - 2006 16357211
15 - 2025 - 587 - 2006 16357211
15 - 2006 - 531 - 2006 16357211
EXPRESSION
Type
   expressed in (based on citations)
organ(s)
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
HOMOLOGY
Homologene
FAMILY
CATEGORY structural protein
SUBCELLULAR LOCALIZATION extracellular
    plasma membrane
basic FUNCTION
  • participates in Hedgehog-mediated patterning of the neural tube
  • plays an additional role in repressing Hh pathway activity
  • essential for ciliogenesis in some, but not all, tissues
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • forms a complex with multiple ciliopathy proteins associated with Meckel and Joubert syndromes
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) JBTS13
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS