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FLASH GENE
Symbol UBXN2B contributors: mct - updated : 18-05-2011
HGNC name UBX domain protein 2B
HGNC id 27035
DNA
TYPE functioning gene
STRUCTURE 40.24 kb     8 Exon(s)
MAPPING cloned Y linked N status provisional
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
8 - 5088 - 331 - 2010 20875789
EXPRESSION
Type
   expressed in (based on citations)
organ(s)
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
HOMOLOGY
Homologene
FAMILY
CATEGORY DNA associated
SUBCELLULAR LOCALIZATION     intracellular
intracellular,cytoplasm,organelle,endoplasmic reticulum
intracellular,cytoplasm,organelle,Golgi
intracellular,cytoplasm,cytosolic
intracellular,nucleus
basic FUNCTION
  • required for Golgi and ER biogenesis
  • plays an important role in both Golgi and ER maintenance during interphase as well as in their reassembly at the end of mitosis
  • its phosphorylation on Serine-56 and Threonine-59 is important for Golgi disassembly at mitosis
  • UBXN2B/NSFL1C adaptors of VCP regulate mitosis by limiting the centrosomal recruitment of AURKA
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • forms a complex with VCP in the cytosol and localizes to the Golgi and ER
    • INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    Other mitotically phosphorylated by CDK1
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS