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FLASH GENE

Symbol

IL6R

contributors: mct - updated : 13-09-2017

HGNC name	interleukin 6 receptor
HGNC id	6019

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

DNA

TYPE	functioning gene
STRUCTURE	62.00 kb     10 Exon(s)

Genomic sequence alignment details
10 Kb 5' upstream gene genomic sequence study

MAPPING

cloned

Y

linked

status

confirmed

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed V1 - - 4176 - 468 - Ruggeri V2 - - 4082 - 365 expressed in peripheral blood mononuclear cells and weakly found in urine and serum Ruggeri

EXPRESSION

Type

widely

constitutive of

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Lymphoid/Immune spleen       highly Respiratory respiratory tract larynx     highly

cell lineage

cell lines

fluid/secretion

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains

mono polymer

heteromer , dimer

HOMOLOGY

Homologene

FAMILY

CATEGORY

signaling cytokine , receptor

SUBCELLULAR LOCALIZATION	extracellular
	plasma membrane
	intracellular
	intracellular,nucleus

basic FUNCTION

involved in the regulation of the immune response, acute-phase reactions and hematopoiesis

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

a component	heterodimerizing with IL6ST
	hexamer of two molecules each of IL6, IL6R and IL6ST

INTERACTION

DNA

RNA

small molecule

protein

TRAF5 is a negative regulator of the IL6R signaling pathway that limits the induction of proinflammatory CD4(+) T cells that require IL6 for their development

cell & other

REGULATION

ASSOCIATED DISORDERS

ANIMAL & CELL MODELS