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FLASH GENE
Symbol RNF180 contributors: mct - updated : 06-09-2010
HGNC name ring finger protein 180
HGNC id 27752
DNA
TYPE functioning gene
STRUCTURE 207.03 kb     8 Exon(s)
MAPPING cloned Y linked N status provisional
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
5 - 1453 47.3 416 - Ogawa (2008)
8 - 4944 68.1 592 - Ogawa (2008)
EXPRESSION
Type widely
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Nervousbrain    
Reproductivefemale systemuterus   
 male systemtestis   
Urinarykidney    
cell lineage
cell lines
fluid/secretion
at STAGE
physiological period embryo, fetal
Text in developing lens and brain, particularly in the ventricular layer of the cerebral cortex at embryonic stages (Ogawa 2008)
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • a RING finger domain
  • a basic coiled-coil domain
  • a novel conserved domain (DSPRC)
  • a C-terminal hydrophobic region that is predicted to be a transmembrane domain (Ogawa 2008)
  • HOMOLOGY
    Homologene
    FAMILY
    CATEGORY transcription factor
    SUBCELLULAR LOCALIZATION     plasma membrane
        intracellular
    intracellular,cytoplasm,organelle,membrane
    intracellular,nucleus
    intracellular,nuclear envelope
    basic FUNCTION
  • membrane-bound E3 ubiquitin ligase, involved in the ubiquitin-proteasome pathway (Ogawa 2008)
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS