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FLASH GENE
Symbol KDM7A contributors: shn/mct - updated : 22-02-2017
HGNC name lysine demethylase 7A
HGNC id 22224
DNA
TYPE functioning gene
STRUCTURE 92.19 kb     20 Exon(s)
MAPPING cloned Y linked N status confirmed
Map cen - D7S2468 - D7S2202 - JHDM1D - D7S1824 - D7S2513 - qter
RNA
TRANSCRIPTS type
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
20 - 9178 110 941 - 2010 20194436
EXPRESSION
Type
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Cardiovascularheart   lowly
Digestiveintestinesmall intestine  moderately
 liver   moderately
Lymphoid/Immunespleen   lowly
Nervousbrainhindbraincerebellum predominantly
Reproductivemale systemseminal vesicles  moderately
Respiratorylung   lowly
Urinarykidney   moderately
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • a JmjC domain
  • 1 PHD-type zinc finger
  • a predicted Fe(II)- and a alpha-ketoglutarate (á-KG)-binding sites
    • HOMOLOGY
    interspecies ortholog to LOC321248, Danio rerio
    Homologene
    FAMILY
  • JHDM1 histone demethylase family
  • JmjC domain-containing proteins subfamily
    • CATEGORY transcription factor
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,nucleus,nucleoplasm
    intracellular,nucleus,nucleolus
    basic FUNCTION
  • as a novel histone demethylase specific for these two repressing marks
  • might contribute to transcriptional regulation of genes in the nervous system
  • might regulate the proliferation or differentiation of neurons and plays an important role in brain development
  • ability to mediate the direct removal of methyl groups from H3K9me2/me1 and H3K27me2/me1
  • co-activator function having important functional roles in neuronal development
  • modifies the level of methylation in histone and participates in epigenetic gene regulation
  • plays a tumor-suppressive role by regulating angiogenesis
  • KDM7A regulates ICAM1 protein stability via a lysosome-dependent pathway
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS development , nervous system
    text histone demethylase activity
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
  • regulates transcription and H3K9me2 and H3K27me2 levels of the follistatin gene
    • small molecule
    protein
  • pro-neural differentiation effect of KDM7A is mediated through direct transcriptional activation of FGF4, a signal molecule implicated in neural differentiation
  • KDM6B and KDM7A play a role in localizing elongation factors SUPT6H and SUPT16H to the target genes
  • EHMT2 orchestrates PHF19 and KDM7A to promote histone H3K27 methylation
  • role of KDM7A in ICAM1 protein stabilization
  • mediates TNF-induced ICAM1 protein upregulation mediated by induction of KDM7A, which regulates the TFEB-mediated lysosomal activity
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    constitutional     --over  
    transcript levels were positively correlated with disease activity in systemic lupus erythematosus
    constitutional     --over  
    accelerated neural differentiation
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    SystemTypeDisorderPubmed
    cancer  
    increased KDM7A expression suppressed tumor growth by down-regulating angiogenesis under nutrient starvation
    ANIMAL & CELL MODELS
  • splicing-blocking antisense morpholino oligonucleotides that targeting Zebrafish KDM7 ortholog lead to a curly tail and marked decrease in size of the tectum with loss of neurons
  • depletion of KDM7 by RNAi in primary cultured mouse neurons also resulted in down-regulation of follistatin mRNA