Selected-GenAtlas references | SOURCE | GeneCards | NCBI Gene | Swiss-Prot | Orphanet | Ensembl |
HGNC | UniGene | Nucleotide | OMIM | UCSC |
Home Page |
FLASH GENE |
Symbol | CFI | contributors: mct/npt - updated : 25-01-2022 |
HGNC name | complement factor I |
HGNC id | 5394 |
|
DNA |
TYPE | functioning gene |
STRUCTURE | 61.49 kb 13 Exon(s) |
MAPPING | cloned | Y | linked | Y | status | confirmed |
Map | cen - GC - CXCL10 - ADH5 - EGF - IF - IL2 IL2 - MNS - qter |
Authors | Shiang (99) |
RNA |
TRANSCRIPTS | type | messenger |
---|
EXPRESSION |
Type | restricted |
expressed in | (based on citations) | ||||||||||||||||||||||||||||||||||||||||
organ(s) |
|
cell lineage
cell lines
| fluid/secretion
| plasma | |
at STAGE |
PROTEIN |
PHYSICAL PROPERTIES
STRUCTURE
| |
motifs/domains
| |
| |
|
conjugated | GlycoP |
mono polymer | heteromer , dimer |
isoforms | Precursor | with two alternatively spliced isoforms C3I alpha, C3I beta |
HOMOLOGY |
Homologene |
FAMILY | |
|
CATEGORY | enzyme |
SUBCELLULAR LOCALIZATION | extracellular |
plasma membrane | |
intracellular | |
intracellular,cytoplasm |
basic FUNCTION | |
| |
| |
| |
| |
|
CELLULAR PROCESS | protein, degradation |
PHYSIOLOGICAL PROCESS | immunity/defense |
text | |
|
PATHWAY |
metabolism |
signaling |
a component | |
|
INTERACTION |
DNA |
RNA |
small molecule | cofactor, |
protein |
cell & other |
REGULATION |
Other | markedly activated HF1 and MCP (membrane cofactor protein) |
ASSOCIATED DISORDERS |
corresponding disease(s) | CFID |
Other morbid association(s) |
|
Susceptibility |
|
Variant & Polymorphism other | |
Candidate gene
Marker
| Therapy target
|
| |
ANIMAL & CELL MODELS |