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FLASH GENE
Symbol CDKN2B-AS1 contributors: mct/npt/pgu - updated : 27-11-2014
HGNC name CDKN2B antisense RNA (non-protein coding)
HGNC id 34341
DNA
TYPE small rna
SPECIAL FEATURE opposite orientation
text
  • a first exon located in the promoter of the p14/ARF gene and overlapping the two exons of p15/CDKN2B
  • overlaps and is transcribed in antisense with respect to CDKN2B
  • MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type untranslated transfer
    EXPRESSION
    Rna function
  • CARD8 is a downstream target gene regulated by CDKN2B-AS1
  • Type
       expressed in (based on citations)
    organ(s)
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    HOMOLOGY
    Homologene
    FAMILY
    CATEGORY
    SUBCELLULAR LOCALIZATION
    basic FUNCTION modulation of ANRIL expression mediates susceptibility to a range of important human diseases
    CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • expression levels of CDKN2A, CDKN2B, and CDKN2BAS are positively correlated
  • within the polycomb repressive complex 1 binds to CDKN2BAS and both CBX7 and CDKN2BAS are found at elevated levels in prostate cancer tissues
  • cell & other
    REGULATION
    Other its effects may be mediated through antisense transcription regulation of CDKN2B in the tissues critical for the pathogenesis of the different diseases
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility
  • to risk for aggressive periodontitis
  • to coronary artery disease (CAD) and periodontitis
  • Variant & Polymorphism other
  • specific variants associated with highly increased risk for aggressive periodontitis (AgP)
  • risk alleles in the genes CDKN2B-AS1, CAMTA1 and PLG that are shared between coronary artery disease (CAD) and periodontitis
  • Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS