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FLASH GENE
Symbol SEMA3G contributors: mct/npt/pgu - updated : 19-05-2017
HGNC name sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3G
HGNC id 30400
DNA
TYPE functioning gene
STRUCTURE 11.78 kb     16 Exon(s)
MAPPING cloned Y linked N status provisional
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
16 - 4700 - 782 - 2008 18818766
EXPRESSION
Type
   expressed in (based on citations)
organ(s)
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
HOMOLOGY
Homologene
FAMILY
  • semaphorin/collapsin family
  • CATEGORY secretory , protooncogene
    SUBCELLULAR LOCALIZATION extracellular
        plasma membrane
    basic FUNCTION
  • can function as potent anti-tumorigenic agents (but is required expression of appropriate semaphorin receptors by tumor cells)
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • binds Neuropilin-2, but not Neuropilin-1, and induces the repulsion of sympathetic axons, but not dorsal root ganglion axons (Sema3G utilizes neuropilin-2 as a receptor to repel specific types of axons)
  • interacting with HLX (HLX strongly increased the transcripts for several repulsive cell-guidance proteins including UNC5B, plexin-A1, and SEMA3G)
  • SEMA3G induces cell collapse in an NRP2/PLXND1-dependent manner
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility
    Variant & Polymorphism
    Candidate gene only significant prognostic marker in glial tumors
    Marker
    Therapy target
    ANIMAL & CELL MODELS