basic FUNCTION
| play important roles in the renal tubular secretion of cationic drugs |
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able to transport tetraethylammonium (TEA) utilizing an oppositely directed H+ gradient as a driving force |
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play crucial roles in the renal handling of cationic drugs, such as cimetidine, metformin and oxaliplatin |
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function together as a detoxication system, by mediating the tubular secretion of intracellular ionic compounds across the brush-border membranes of the kidney |
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kidney-specific H+/organic cation antiporter that is responsible for the tubular secretion of cationic drugs across the brush border membranes |
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responsible for the final step in the excretion of metabolic waste and xenobiotic organic cations in the kidney and liver through electroneutral exchange of H(+) |