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FLASH GENE
Symbol SLC46A1 contributors: mct/npt/pgu - updated : 20-07-2009
HGNC name solute carrier family 46 (folate transporter), member 1
HGNC id 30521
DNA
TYPE functioning gene
STRUCTURE 11.57 kb     5 Exon(s)
regulatory sequence Promoter
cytosine-phosphate-guanine/HTF
text structure
  • basal promoter is rich in functional GC-box sites that play a key role in regulation of SLC46A1 gene expression
  • MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    5 - 6505 - 459 - 2009 19074442
    EXPRESSION
    Type widely
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Endocrineadrenal gland   highly
     parathyroid   highly
    Lymphoid/Immunespleen   highly
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
    HOMOLOGY
    Homologene
    FAMILY
  • major facilitator superfamily
  • SLC46A family
  • CATEGORY transport carrier channel
    SUBCELLULAR LOCALIZATION     plasma membrane
    basic FUNCTION
  • having a critical role to intestinal folate absorption and transport into the central nervous system
  • might play also a role in another transport pathway, folate receptor (FR)-mediated endocytosis
  • mediates intestinal folate uptake at acidic pH
  • NRF1-responsive gene
  • functions as a folate-proton co-transporter in the acidic microclimate of the upper small intestine
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) CFM
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS