SUBCELLULAR LOCALIZATION
| intracellular
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| intracellular,cytoplasm,cytosolic,vesicle
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| intracellular,cytoplasm,cytoskeleton,microtubule,mitotic spindle
|
| intracellular,nucleus,nucleoplasm
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| intracellular,nucleus,nucleolus
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| concentrated in the nucleolus during interphase and distributed in the perichromosome and cytoplasm during mitosis |
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found in cytoplasmic vesicles, and it decorates the spindle in mitosis |
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is a nuclear and nucleolar protein |
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translocates from the nucleoli in interphase to the spindle in mitosis as an RNA-protein complex that includes 18S ribosomal RNA |
basic FUNCTION
| RNA methyltransferase catalysing intron-dependent m5C formation in the first position of the anticodon of the pre-tRNA Leu (CAA) |
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nucleolar RNA methyltransferase important for MYC-induced proliferation in skin |
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RNA methyltransferase required to balance stem cell self-renewal and differentiation in skin |
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essential for elevating CDKN2A expression levels, and NSUN2-mediated methylation of the CDKN2A 3primeUTR is a novel mechanism to stabilize CDKN2A mRNA |
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implicated in the development of higher cognitive functions |
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catalyzes formation of 5-methylcytosine at C34 of tRNA-leu(CAA) and plays a role in spindle assembly during mitosis as well as chromosome segregation |
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implicated in MYC-induced cell proliferation and mitotic spindle stability |
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is an RNA methyltransferase known to operate downstream of MYC during cell proliferation |
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is an RNA methyltransferase modifying cytosine-5 in transfer RNAs (tRNAs) |
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NSUN2 and METTL1, are required for protecting tRNA against tRNA decay (RTD) |
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critical impact of NSUN2-mediated mRNA methylation in promoting premature senescence |
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nucleolar RNA methyltransferase, has been shown to methylate mRNAs encoding factors that control cell division and growth arrest, thereby affecting their stability and/or translation |