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FLASH GENE
Symbol SLC2A2 contributors: mct - updated : 28-05-2014
HGNC name solute carrier family 2 (facilitated glucose transporter), member 2
HGNC id 11006
DNA
TYPE functioning gene
STRUCTURE 30.63 kb     10 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked N status confirmed
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
10 - 3176 - 405 - 2002 12135767
10 - 3314 - 351 - 2002 12135767
11 - 3439 - 524 - 2002 12135767
EXPRESSION
Type
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Digestiveliver   highly Homo sapiens
Endocrinepancreas   predominantly Homo sapiens
Urinarykidney   highly Homo sapiens
cells
SystemCellPubmedSpeciesStageRna symbol
 epithelial cell
Endocrineislet cell (alpha,beta...) Homo sapiens
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • twelve putative transmembrane segments (12TM)
  • intracellular N and C termini
  • a large extracellular loop with a glycosylation site between TM1 and 2
  • a small and a large intracellular loops,respectively between TM2 and 3 and TM8 and 9,both with the conserved RXGRR motif
  • conjugated GlycoP
    HOMOLOGY
    interspecies homolog to murine Slc2a2
    Homologene
    FAMILY solute carrier family 2 (sugar transporter family), glucose transporter subfamily
    CATEGORY transport carrier
    SUBCELLULAR LOCALIZATION     plasma membrane
        intracellular
    intracellular,cytoplasm
    text basolateral membrane
    basic FUNCTION
  • facilitated glucose transporter, involved in glucosamine transport
  • is responsible for uptake of glucose by the beta cells
  • may comprise part of the glucose-sensing mechanism of the beta cell
  • may also participate with the Na(+)/glucose cotransporter in the transcellular transport of glucose in the small intestine and kidney
  • functions as part of the glucose sensing mechanism for the stimulation of insulin secretion (pMID: 19477941)
  • is unlikely to be the principal glucose transporter in human beta-cells
  • important role of SLC2A2 transporter fueling metabolism at body level
  • role important during embryonic period for differentiation of insulin-producing cells and insulin secretion
  • having functions in pancreatic beta cell development
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS facilitated diffusion transport
    PATHWAY
    metabolism carbohydrate
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • hyperglycemia directly affects beta-cell function and activates a trafficking pathway that results in the rapid endocytosis and degradation of the cell surface SLC2A2 glucose transporter
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) FBIS
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    constitutional germinal mutation     loss of function
    biallelic SLC2A2 inactivation causes lethal neonatal diabetes
    Susceptibility
    Variant & Polymorphism SNP
  • are associated with the conversion from impaired glucose tolerance to type 2 diabetes
  • polymorphisms at positions -269, -44, or + 103 may affect GLUT2 gene transcription, possibly associated with reduced expression of the GLUT2 gene in NIDDM patients
  • Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS
    homozygous mice deficient in GLUT2 are hyperglycemic and relatively hypoinsulinemic and have elevated plasma levels of glucagon, free fatty acids, and beta-hydroxybutyrate