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FLASH GENE
Symbol CCDC88B contributors: mct - updated : 05-02-2009
HGNC name coiled-coil domain containing 88B
HGNC id 26757
DNA
TYPE functioning gene
STRUCTURE 17.31 kb     27 Exon(s)
MAPPING cloned Y linked N status provisional
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
27 - 4927 164.6 1476 - Simpson (2005)
EXPRESSION
Type widely
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Cardiovascularheart     Homo sapiens
Endocrinethyroid   highly
Lymphoid/Immunelymph node   highly
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Blood / hematopoietic    
cells
SystemCellPubmedSpeciesStageRna symbol
Cardiovascularendothelial cell Homo sapiens
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • N-terminus containing a putative microtubule-binding domain that can bind microtubules in the Hook protein
  • the central region of each protein is comprised of an extensive coiled-coil domain
  • several conserved domains, including a unique C-terminal HkRP domain (Simpson 2005)
  • HOMOLOGY
    Homologene
    FAMILY
  • Hook-related protein (HkRP) family, CCDC88 family
  • Girdin family protein
  • CATEGORY unknown/unspecified
    SUBCELLULAR LOCALIZATION
    basic FUNCTION
  • may be functioning in linking organelles to microtubules*
  • having a protective role in endoplasmic reticulum stress responses in endothelial cells
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component CCDC88B/GRP78 interaction controls the IRE1-JNK signaling pathway to protect endothelial cells against ER stress-induced apoptosis in pathological contexts such as atherosclerosis and vascular endothelial dysfunction
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • in endothelial cells, interacts with GRP78, a master regulator of the unfolded protein response
  • stabilizes the interaction between GRP78 and the ER stress sensor inositol-requiring protein 1 (IRE1) at the ER, leading to the attenuation of IRE1-induced c-Jun N-terminal kinase (JNK) activation
  • cell & other
    REGULATION
    induced by upon ER stress
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS