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FLASH GENE
Symbol SMDT1 contributors: mct - updated : 30-05-2016
HGNC name single-pass membrane protein with aspartate-rich tail 1
HGNC id 25055
DNA
TYPE functioning gene
STRUCTURE 4.59 kb     3 Exon(s)
MAPPING cloned Y linked N status provisional
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
3 - 1585 11.21 107 - 2013 24231807
EXPRESSION
Type
   expressed in (based on citations)
organ(s)
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
HOMOLOGY
Homologene
FAMILY
CATEGORY unknown/unspecified
SUBCELLULAR LOCALIZATION     plasma membrane
    intracellular
intracellular,cytoplasm,organelle,mitochondria,inner
intracellular,cytoplasm,organelle,membrane
intracellular,nucleus
basic FUNCTION
  • is essential for uniporter current and additionally bridges the calcium-sensing role of MICU1 and MICU2 with the calcium-conducting role of MCU
  • its known MCU-activating function is mediated by the interaction of transmembrane helices from both proteins
  • identified as a uniporter subunit absolutely required for Ca2+ permeation
  • its second function is to maintain tight MICU1, MICU2 regulation of the MCU pore, a role that requires SMDT1 to bind MICU1 using its conserved C-terminal polyaspartate tail
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • was required for the interaction of MCU with MICU1 and MICU2
  • MICU1 is a key regulator of the mitochondrial Ca(2+) uniporter (MCU) that together with the essential MCU regulator (SMDT1) forms the mitochondrial Ca(2+) channel
  • MCU channel activity is governed by matrix Ca(2+) concentration through SMDT1
  • SMDT1-dependent regulation of MCU channel activity requires intermembrane space-localized MICU1, MICU2, and cytoplasmic Ca(2+)
  • MCUR1 binds to MCU and SMDT1 and function as a scaffold factor
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS