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FLASH GENE
Symbol SH3RF3 contributors: mct - updated : 02-03-2011
HGNC name SH3 domain containing ring finger 3
HGNC id 24699
DNA
TYPE functioning gene
STRUCTURE 319.94 kb     8 Exon(s)
MAPPING cloned   linked   status
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
8 - 5608 - 882 - Karkkainen (2006)
EXPRESSION
Type ubiquitous
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Cardiovascularheart   highly Homo sapiens
Digestiveliver   highly Homo sapiens
Endocrinepancreas     Homo sapiens
Lymphoid/Immunespleen     Homo sapiens
 thymus     Homo sapiens
Nervousbrain   highly Homo sapiens
 spinal cord     Homo sapiens
Respiratorylung     Homo sapiens
Urinarykidney     Homo sapiens
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Blood / hematopoieticbone marrow    Homo sapiens
Muscularstriatumskeletal   Homo sapiens
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • a conserved N-terminal extension with GTP-loaded Rac1 binding activity and acting as a partial CRIB domain
  • four SH3 domains as well as a RING domain
  • a functional RING domain, that transfers E3 ligase activity to this protein, with Cys3HisCys4 AAs that is also found in SH3RF1 and SH3RF2
  • HOMOLOGY
    intraspecies homolog to c-Jun N-terminal kinase scaffold protein POSH (SH3RF1)
    Homologene
    FAMILY
    CATEGORY adaptor , signaling
    SUBCELLULAR LOCALIZATION
    basic FUNCTION
  • signalling protein, PAK2-binding adaptor protein
  • scaffold protein that enhances JNK activation and apoptosis
  • may regulate JNK activation and consequent apoptosis under conditions of increased expression
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • can interact with GTP-loaded Rac using only a partial CRIB domain
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS