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FLASH GENE
Symbol TMEM107 contributors: mct - updated : 24-08-2017
HGNC name transmembrane protein 107
HGNC id 28128
DNA
TYPE functioning gene
STRUCTURE 3.42 kb     5 Exon(s)
MAPPING cloned Y linked N status provisional
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
5 - 1776 16 146 - 2012 2269854
5 - 1758 15.4 140 - 2012 2269854
- - 2288 - 139 - -
- - 2270 - 133 - -
- - 2093 - 74 - -
EXPRESSION
Type
   expressed in (based on citations)
organ(s)
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Blood / hematopoieticbone marrow   
cell lineage
cell lines
fluid/secretion blood
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
HOMOLOGY
Homologene
FAMILY
CATEGORY structural protein
SUBCELLULAR LOCALIZATION     plasma membrane
    intracellular
intracellular,cytoplasm,cytoskeleton,intermed filament
basic FUNCTION
  • acts in combination with GLI2 and GLI3 to pattern ventral and intermediate neuronal cell types
  • acts in the SHH pathway to determine digit number, but not identity, by regulating a subset of SHH target genes
  • is a novel factor required for ciliogenesis and Sonic hedgehog signaling
  • plays a key, conserved role in regulating ciliary protein composition
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) JBTS29 , OFD16 , MKS13
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS