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FLASH GENE
Symbol DNLZ contributors: mct/npt - updated : 07-12-2011
HGNC name DNL-type zinc finger
HGNC id 33879
DNA
TYPE functioning gene
STRUCTURE 1.89 kb     3 Exon(s)
MAPPING cloned Y linked N status provisional
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
3 - 724 19.1 178 - 2011 21530495
EXPRESSION
Type restricted
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Digestivesalivary gland    
Reproductivefemale systemuteruscervix  
 male systemprostate   
Urinarykidney    
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES globular
STRUCTURE
motifs/domains
  • an N-terminal ATPase domain, predicted to constitute a mitochondrial localization signaling sequence
  • a ZBS domain required to form a stable complex with the HSPA9 ATPase domain, and ATP hydrolysis measurements reveal that the ZBS is critical for full stimulation of HSPA9 catalytic activity
  • a conserved histidine as critical for DNLZ regulation of mitochondrial HSPA9 catalytic activity
  • a C-terminal peptide-binding domain
  • HOMOLOGY
    interspecies ortholog to S. Cerevisiae Zim17
    Homologene
    FAMILY
  • hsp70 protein family
  • CATEGORY chaperone/stress
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,mitochondria
    basic FUNCTION
  • exhibits limited solubility due to aggregation mediated by its ATPase domain and directly enhances chaperone solubility through interactions with this domain
  • promote chaperone solubility through interactions with the ATPase domain
  • enhances the HSPA9 rate of ATP hydrolysis
  • cochaperone that controls the rate at which HSPA9 converts between its low peptide affinity (ATP bound) and high peptide affinity (ADP bound) conformations
  • regulates the catalytic activity and solubility of the mitochondrial hsp70 chaperone HSPA9
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS