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FLASH GENE
Symbol EMC10 contributors: mct - updated : 22-03-2016
HGNC name ER membrane protein complex subunit 10
HGNC id 27609
DNA
TYPE functioning gene
STRUCTURE 29.45 kb     8 Exon(s)
MAPPING cloned Y linked N status provisional
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
8 - 2211 26.7 254 - 2011 20680400
HSS1
7 - 2124 27.2 262 - 2011 20680400
HSM1
EXPRESSION
Type
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Endocrinepancreas     Rattus norvegicus
Reproductivemale systemtestis    Rattus norvegicus
Urinarybladder     Rattus norvegicus
cells
SystemCellPubmedSpeciesStageRna symbol
Endocrineislet cell (alpha,beta...) Rattus norvegicus
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
HOMOLOGY
Homologene
FAMILY
CATEGORY DNA associated
SUBCELLULAR LOCALIZATION extracellular
    intracellular
intracellular,cytoplasm,organelle,membrane
intracellular,cytoplasm,organelle,endoplasmic reticulum
basic FUNCTION
  • is likely is associated with functions of pancreatic islets, especially of beta-cells
  • is a truly novel protein defining a new class of secreted factors, and it may have an important role in cancer, particularly glioma
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --over  
    modulates signaling pathways involved in tumorigenesis
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    SystemTypeDisorderPubmed
    cancerbrainglioma/neuroblstoma
    is a potential therapeutic for malignant glioblastoma possessing significant antitumor and anti-angiogenic activity
    ANIMAL & CELL MODELS