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FLASH GENE
Symbol SEMG1 contributors: mct - updated : 13-02-2018
HGNC name semenogelin I
HGNC id 10742
DNA
TYPE functioning gene
SPECIAL FEATURE arranged in tandem
text located 5' to SEMG2 in a head to tail arrangement
STRUCTURE 2.80 kb     3 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked N status confirmed
regionally located tightly linked to SEMG2
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
3 - 1696 - 462 - 2013 24312623
EXPRESSION
Type restricted
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Reproductivemale systemseminal vesicles  highly
 male systemmale genital tractepididymis  
 male systemprostate   
 male systemmale genital tractvas deferens  
Respiratoryrespiratory tracttrachea   
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Muscularstriatumskeletal  
cell lineage
cell lines
fluid/secretion in human semen coagulum
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
HOMOLOGY
interspecies homolog to murine Syp1
Homologene
FAMILY semenogelin family
CATEGORY secretory
SUBCELLULAR LOCALIZATION extracellular
    intracellular
intracellular,nucleus
basic FUNCTION
  • formation of a gel matrix entrapping the accessory gland secretion and ejaculated spermatozoa
  • antibacterial activity of the SEMG1-derived peptides generated in seminal plasma was strictly zinc-dependent both at neutral and low pH
  • in sperm modifies the membrane structure, indirectly inhibiting motility
  • EPPIN and SEMG1 rapidly co-evolved in primates due to their critical role in the modulation of sperm motility in the semen coagulum
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component major constituent protein of seminal fluid
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • rapidly cleaved after ejaculation by KLK3, resulting in liquefaction of the semen coagulum and
  • the progressive release of motile spermatozoa
  • binding semenogelins II and zinc and regulate the activity of prostate-specific antigen (KLK3)
  • cleaved by KLK14
  • during ejaculation SEMG (semenogelin) from the seminal vesicles binds to the EPPIN protein complex, initiating a series of events that define EPPIN function
  • EPPIN controls sperm motility in the ejaculate by binding SEMG1, resulting in the loss of calcium, most likely through a disturbance of internal pH and an inhibition of uptake mechanisms
  • EPPIN's sequence C102-P133 contains the major binding site for SEMG1
  • interaction between PIP and SEMG1 fragments in seminal plasma or elsewhere with a suggestive role in reproductive physiology which might be helpful for spermatozoa to acquire their motility
  • physiological significance of the SEMG1/EPPIN interaction on the surface of spermatozoa is its capacity to modulate sperm progressive motility
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --over  
    in nearly half of patients with early Chronic lymphocytic leukemia (CLL)
    Susceptibility
    Variant & Polymorphism
    Candidate gene
  • candidate gene for the development of diagnostic marker and provided the opportunity to further illustrate the biological mechanisms of asthenozoosperm
  • Marker
  • use of SEMG1 as a novel biomarker for renal cell carcinoma
  • Therapy target
    ANIMAL & CELL MODELS