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FLASH GENE
Symbol ACTG2 contributors: mct - updated : 24-08-2017
HGNC name actin, gamma 2, smooth muscle, enteric
HGNC id 145
DNA
TYPE functioning gene
STRUCTURE 26.69 kb     9 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked N status confirmed
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
9 - 1345 - 376 - 2016 27107594
8 - 1216 - 333 - 2016 27107594
EXPRESSION
Type
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Digestiveintestinesmall intestine  highly
 intestinelarge intestinecolon highly
Reproductivemale systemprostate  highly
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Muscularsmoothmuscularis mucosa (tractus digestif) highly
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
HOMOLOGY
Homologene
FAMILY actin family
CATEGORY structural protein
SUBCELLULAR LOCALIZATION extracellular
    intracellular
intracellular,cytoplasm,cytosolic
basic FUNCTION
  • being mediator of internal cell motility
  • its expression in HCC is strongly correlated with the Epithelial-Mesenchymal Transition (EMT) process, hepatocellular carcinoma (HCC) aggressiveness and the identification of cancer stem cells
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component component of the cytoskeleton
    INTERACTION
    DNA
    RNA
    small molecule
    protein target of NKX 3.1 regulatory activity (activity in prostate epithelia is due, in part, to the androgen-dependent expression of NKX3.1)
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) MMIH2
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --over  
    in androgen-responsive LNCaP cancer
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
  • represents a novel and powerful marker to predict HCC progression
  • Therapy target
    SystemTypeDisorderPubmed
    cancerdigestiveliver
    novel target for the treatment of HCC
    ANIMAL & CELL MODELS