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FLASH GENE
Symbol IBSP contributors: mct - updated : 13-10-2014
HGNC name integrin-binding sialoprotein (bone sialoprotein, bone sialoprotein II)
HGNC id 5341
DNA
TYPE functioning gene
SPECIAL FEATURE arranged in tandem
text SIBLINGs share many common features, such as their tandem gene location
STRUCTURE 12.00 kb     7 Exon(s)
10 Kb 5' upstream gene genomic sequence study
regulatory sequence Promoter
Binding site   transcription factor
text structure
  • FGF2 increases IBSP transcription by targeting the FRE and AP1 elements in the proximal promoter of the human IBSP gene
  • MAPPING cloned Y linked Y status confirmed
    regionally located closely linked to SPP1
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    7 - 1595 - 317 - 2003 13679028
    EXPRESSION
    Type restricted
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Hearing/Equilibriumearinnercochlea  
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Connectivebonesubchondral  
    Connectivecartilage   
    cells
    SystemCellPubmedSpeciesStageRna symbol
    Digestiveodontoblast Homo sapiensFetal
    Skeletonosteoblast Homo sapiensFetal
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    physiological period fetal
    Text cochlea
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • multiple phosphorylation sites
  • disulfide-free flexible hydrophilic structures
  • presence of the integrin-binding tripeptide, arginine-glycine-aspartate (RGD)
  • conjugated GlycoP
    HOMOLOGY
    interspecies homolog to murine Ibsp
    Homologene
    FAMILY SIBLING family (small integrin binding ligang N linked glycoprotein)
    CATEGORY adhesion , structural protein
    SUBCELLULAR LOCALIZATION extracellular
        plasma membrane
    text bone matrix protein
    basic FUNCTION
  • mediating cell attachment through an RGD sequence that recognizes the vitronectin receptor
  • involved in bone mineralization and remodeling
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS development , ossification
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule metal binding,
    calcium Ca2+
    protein
  • MSX2, RUNX2 and SMADl transcription factors appear to be key regulators of IL11 effects on IBSP transcription
  • KDM6B plays important roles in osteoblast differentiation and regulates the expressions of IBSP and BGLAP via transcription factors RUNX2 and SP7
  • ESR1 stimulates likely IBSP gene transcription in a ligand-independent manner by targeting the CRE and AP1/GRE elements in the IBSP gene promoter
  • cell & other binding to hydroxyapatite
    REGULATION
    Other regulated by RUNX2 in osteoblasts
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    constitutional     --over  
    during early bone formation and may play a role in primary mineralization of bone
    constitutional     --low  
    affects both osteoclast formation and activity
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS
  • adult Ibsp-knockout mice (BSP-/-) display shorter stature, lower bone turnover and higher trabecular bone mass than wild type, the latter resulting from impaired bone resorption