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FLASH GENE
Symbol CENPB contributors: mct - updated : 02-05-2018
HGNC name centromere protein B, 80kDa
HGNC id 1852
DNA
TYPE functioning gene
SPECIAL FEATURE component of a cluster, antisens
STRUCTURE 2.84 kb     1 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked N status confirmed
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
1 - 2856 - 599 - 2015 25916850
EXPRESSION
Type widely
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Digestivesalivary gland   highly
Reproductivemale systemprostate  highly
Skin/Tegumentskin   highly
Visualeye   highly
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Connectivebone   
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • sequence homolog to transposases of the pogo superfamily,
  • binding a 18bp sequence (CENP-B box) in alpha-satellite DNA
  • a DNA-binding domain
  • HOMOLOGY
    Homologene
    FAMILY
    CATEGORY structural protein
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,nucleus,nucleoplasm,nuclear bodies
    intracellular,nucleus,chromatin/chromosome,heterochromosome
    intracellular,nucleus,chromatin/chromosome,centromere
    basic FUNCTION
  • playing an important role in the assembly of specific centromere structures in interphase nuclei and on mitotic chromosomes
  • may be a determinant for translational positioning of the centromere-specific nucleosomes through its binding to the nucleosomal CENP-B box
  • functional CENPB paralogues is highly unlikely and CENPB acts alone at the centromere
  • CENPB functions positively in the de novo assembly of centromeric nucleosomes, containing the centromere-specific histone H3 variant, CENPA
  • is a highly conserved protein that facilitates the assembly of specific centromere structures both in interphase nuclei and on mitotic chromosomes
  • DNA sequence-specific enhancement by CENPB of the fidelity of epigenetically defined human centromere function
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • CENPA and CENPB are major components of centromeric chromatin
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • interaction between CENPB and CENPC may be involved in the correct assembly of CENPC on alphoid DNA
  • CENP-B is a CCR3 ligand (CENPB transactivation of the EGFR via CCR3 in vascular smooth muscle cells
  • PARP1 interaction with CENPB, CENPE, and CENPF during mitosis and apoptosis
  • IL8 inhibited the non-specific binding of CENPB to nucleosomes and apparently stimulated CENPB binding to its cognate CENPB box DNA in nucleosomes
  • METTL11A is a major enzyme required for the CENPB methylation
  • highly conserved protein which can bind to the 17-bp CENPB box on the centromeric DNA
  • PLR3B interacts with CENPB and promotes cleavage of the N-terminal DNA binding domain from CENPB
  • CENPB specifically binds to the CENPB box DNA sequence on the centromere-specific repetitive DNA
  • CENPB binding in the vicinity of the CENPA nucleosome substantially stabilizes the CENPA nucleosome on alphoid DNA in human cells
  • CENPB directly binds both CENPA N-terminal tail and CENPC1, a key nucleator of kinetochore assembly
  • TADA3 is required for the loading of CENPB onto the centromeres
  • cell & other
  • associated with most human centromeres
  • specifically binds to the centromeric 17 base-pair CENP-B box DNA, which contains two CpG dinucleotides
  • REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS