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FLASH GENE
Symbol HDLBP contributors: mct/npt - updated : 24-09-2009
HGNC name high density lipoprotein binding protein
HGNC id 4857
DNA
TYPE functioning gene
STRUCTURE 88.58 kb     28 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked N status confirmed
Physical map
LOC391495 2 similar to DNA-directed RNA polymerase II largest subunit LOC150681 2q37.3 similar to Olfactory receptor 6B3 LOC391496 2 similar to olfactory receptor family 9 subfamily S LOC150678 2q37.3 helicase/primase complex protein LOC150677 LOC391497 2 similar to ENSANGP00000007346 GPC1 2q37.3 glypican 1 ANKMY1 2q37.3 ankyrin repeat and MYND domain containing 1 LOC285193 2q37.3 similar to RIKEN cDNA 0710001B24 RNPEPL1 2q37.3 arginyl aminopeptidase (aminopeptidase B)-like 1 CAPN10 2q37.3 calpain 10 GPR35 2q37.3 G protein-coupled receptor 35 LOC285192 2q37.3 similar to aquaporin 11 AQP12 2q37.3 aquaporin 12 ATSV 2q37.3 axonal transport of synaptic vesicles AGXT 2q37.3 alanine-glyoxylate aminotransferase (oxalosis I; hyperoxaluria I; glycolicaciduria; serine-pyruvate aminotransferase) FLJ22671 2q37.3 hypothetical protein FLJ22671 LOC285188 2q37.3 similar to KIAA0445 protein FLJ00133 2q37.3 FLJ00133 protein MGC61716 2q37.3 hypothetical protein MGC61716 PASK 2q37.3 PAS domain containing serine/threonine kinase PPP1R7 2q37.3 protein phosphatase 1, regulatory subunit 7 LOC344525 2q37.3 similar to transmembrane protein 16C; chromosome 11 open reading frame 25 HDLBP 2q37.3 high density lipoprotein binding protein (vigilin) NEDD5 2q37. neural precursor cell expressed, developmentally down-regulated 5 FARP2 2q37.3 FERM, RhoGEF and pleckstrin domain protein 2 STK25 2q37.3 serine/threonine kinase 25 (STE20 homolog, yeast) BOK 2q37.3 BCL2-related ovarian killer LOC391498 2 similar to Involucrin THAP4 2q37.3 THAP domain containing 4 APG4B 2q37.3 cysteine endopeptidase AUT-like isoform 1 DTYMK 2pter-p25.2 deoxythymidylate kinase (thymidylate kinase) ING5 2q37.3 inhibitor of growth family, member 5 GP3ST 2q37.3 inhibitor of growth family, member 5 NEU4 2q37.3 sialidase 4 LOC391499 ATTS1136 similar to EST gb FLJ38379 2q37.3 hypothetical protein FLJ38379 LOC159176 2q37.3 similar to F-box only protein 25
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
28 - 6516 141.31 1268 - Zhou (2008)
28 - 6372 141.31 1268 - Zhou (2008)
EXPRESSION
Type ubiquitous
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Nervousbrain   highly
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Connectivebone  highly
Connectivecartilage  highly
cell lineage proliferating cells
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • fourteen K homology (KH) motif
  • C-terminal domain binding to the histone methyltransferase SUV39H1 (Zhou 2008)
  • conjugated LipoP
    HOMOLOGY
    interspecies homolog to murine Hdlbp
    Homologene
    FAMILY
    CATEGORY transport
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm
    intracellular,nucleus,chromatin/chromosome,heterochromosome
    intracellular,nuclear envelope,int
    text localize to heterochromatin (Wang 2005)
    basic FUNCTION
  • playing a role in cell sterol metabolism
  • may be functioning to protect cells from over-accumulation of cholesterol
  • RNA-binding protein previously implicated in heterochromatin formation and chromosome segregation (Zhou 2008)
  • plays a pivotal role in the endocrine regulation of both lipids and cholesterol (Chen 2003)
  • key regulator in proliferating cells (Felder 2009)
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism lipid/lipoprotein
    signaling
    a component
    INTERACTION
    DNA
    RNA binding
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    constitutional     --low  
    in autism with deletion 2q37.3 (Feider 2009)
    tumoral     --low  
    in gastric cancer
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS