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FLASH GENE
Symbol CBR4 contributors: mct-np - updated : 03/10/2008
HGNC name carbonyl reductase 4
HGNC id 25891
DNA
TYPE functioning gene
STRUCTURE 22.68 kb     5 Exon(s)
MAPPING cloned Y linked N status confirmed
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
5 - 3474 25 237 - -
EXPRESSION
Type
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Digestiveliver     Homo sapiens
Urinarykidney     Homo sapiens
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • non-cleavable mitochondrial targeting signal
  • mono polymer tetramer
    HOMOLOGY
    interspecies homolog to rattus Cbr4 (85.5 pc)
    homolog to murine Cbr4 (86.8 pc)
    Homologene
    FAMILY
  • short-chain dehydrogenases/reductases (SDR) family
  • CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,mitochondria
    basic FUNCTION
  • acting as an oxydoreductase
  • mitochondrial NADPH-dependent quinone reductase
  • may be involved in the induction of apoptosis by cytotoxic 9,10-phenanthrenequinone
  • its localization in the mitochondria that participate in key steps of the apoptotic signal cascade induced by oxidative stress
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule nucleotide,
  • NADP
  • protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS