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FLASH GENE
Symbol CST4 contributors: mct - updated : 13-02-2008
HGNC name cystatin S
HGNC id 2476
DNA
TYPE functioning gene
SPECIAL FEATURE component of a cluster
text seven cystatin genes are clustered within a 300-kb region of 20p11.2
STRUCTURE 3.00 kb     3 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked N status confirmed
regionally located clustered in a space of 900kb
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
3 - 736 - 141 - Dickinson (2002)
EXPRESSION
Type restricted
constitutive of
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Digestivemouth    
 salivary glandparotid   
Reproductivefemale systembreastmammary gland  
Urinarykidney    
Visualeyelacrimal gland   
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Muscularstriatumskeletal  
cell lineage
cell lines tumors endothelial cells
fluid/secretion highly,in saliva,tears,seminal plasma
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • a CREB/AP1 binding site
  • a GT rich region
  • secondary structure two intramolecular disulfide bonds
    conjugated PhosphoP
    HOMOLOGY
    intraspecies paralog to CYST1,CYST2
    Homologene
    FAMILY cystatin type 2 family
    CATEGORY enzyme , secretory
    SUBCELLULAR LOCALIZATION extracellular
    basic FUNCTION cysteine proteinase inhibitor
    CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein strongly ingibiting papain
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS