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FLASH GENE
Symbol ADAT3 contributors: mct/npt - updated : 06-09-2023
HGNC name adenosine deaminase, tRNA-specific 3, TAD3 homolog (S. cerevisiae)
HGNC id 25151
DNA
TYPE functioning gene
STRUCTURE 8.05 kb     2 Exon(s)
MAPPING cloned Y linked N status provisional
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
2 - 1599 - 367 - 2016 26842963
2 - 1408 - 351 - 2016 26842963
EXPRESSION
Type widely
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Lymphoid/Immunespleen   highly
Reproductivemale systemprostate  highly
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Connectiveadipose  highly
Connectivebone  highly
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
HOMOLOGY
interspecies homolog to S. Cerevisiae Tad3
Homologene
FAMILY
  • cytidine and deoxycytidylate deaminase family
  • ADAT3 subfamily
  • CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm
    intracellular,nucleus,nucleoplasm
    text
  • ADAT3 was mainly localized in the cytoplasm, but translocated to nucleus in an ADAT2-dependent manner
  • basic FUNCTION
  • involved in inosine formation in tRNAs
  • with ADAT2 function as a heterodimer which catalyses inosine formation at the wobble position (position 34) in eukaryotic tRNAs
  • playing an essential role for cell viability, illustrating the biological importance of A-to-I editing at the wobble position of tRNA
  • key role for the inactive ADAT3 deaminase domain in proper assembly with ADAT2, demonstrating that ADAT2/3 nuclear import is required for maintaining proper levels of the wobble inosine modification in tRNA
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • heterodimeric enzyme ADAT (hetADAT), is composed of two subunits: ADAT2 and ADAT3 (ADAT2 is considered the catalytic subunit while ADAT3 might be playing a role in tRNA substrate recognition)
  • heterodimer ADAT3 / ADAT2 is involved in the adenosine-to-inosine conversion in tRNA
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) NEDBGF
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS