basic FUNCTION
| involved in inosine formation in tRNAs |
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with ADAT2 function as a heterodimer which catalyses inosine formation at the wobble position (position 34) in eukaryotic tRNAs |
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playing an essential role for cell viability, illustrating the biological importance of A-to-I editing at the wobble position of tRNA |
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key role for the inactive ADAT3 deaminase domain in proper assembly with ADAT2, demonstrating that ADAT2/3 nuclear import is required for maintaining proper levels of the wobble inosine modification in tRNA |