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FLASH GENE
Symbol NABP2 contributors: mct/pgu - updated : 15-04-2015
HGNC name nucleic acid binding protein 2
HGNC id 28412
DNA
TYPE functioning gene
STRUCTURE 5.51 kb     7 Exon(s)
MAPPING cloned Y linked N status provisional
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
7 - 1404 22.3 211 - 2008 18449195
EXPRESSION
Type widely
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Digestivesalivary gland   highly
Reproductivefemale systemuteruscervix highly
cell lineage
cell lines
fluid/secretion
at STAGE
cell cycle     cell cycle, G1, S, G2
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • N-terminal oligosaccharide/oligonucleotide-binding (OB) domain
  • HOMOLOGY
    Homologene
    FAMILY
  • OBFC2 family
  • CATEGORY regulatory , DNA associated
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm
    intracellular,nucleus,nucleoplasm
    basic FUNCTION
  • playing an essential role for a variety of DNA metabolic processes, including replication, recombination, and detection and repair of damage
  • influencing diverse endpoints in the cellular DNA damage response
  • plays a key role in DNA damage response
  • promotes Rad51-mediated strand exchange and may thus contribute directly to homologous recombination repair
  • may also be involved in preventing tumorigenesis and might affect the response of patients and tumours towards radiotherapy and DNA-damaging chemotherapies
  • participating in homologous recombination (HR)-dependent repair of DNA double strand breaks and ATM-mediated checkpoint pathways
  • plays an important role in the DNA damage response and maintenance of genomic stability
  • essential for efficient DNA double-strand break signalling through ATM
  • functions upstream of MRN complex ((RAD50, MRE11, NBS1))to promote its recruitment at DSBs (double-strand break) and is required for efficient resection of DSBs
  • essential roles in controlling ATM activation and activity, and subsequent DSB resection and homologous recombination (HR)
  • essential factor for the initiation of DNA damage checkpoints and the maintenance of genomic stabilityc
  • has a unique function during embryogenesis limited to cell types that contribute to bone formation
  • critical for the initiation of ATM signaling and DNA double-strand break repair by homologous recombination
  • essential roles in embryogenesis, spermatogenesis, and genome stability
  • importance of NABP2 in maintaining and repairing DNA replication forks and for overall genomic stability
  • participate in DNA damage response and maintenance of genome stability by regulating the initiation of ATM-dependent signaling
  • CELLULAR PROCESS nucleotide, replication
    nucleotide, recombination
    nucleotide, repair, recombination
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
  • NABP2 and EEF1E1, might be involved in BRCA1-pathway
  • a component
  • forming a complex with INTS3 and C9orf80, complex required fir efficient HR-dependent repair of DSBs and ATM-dependent signaling pathways
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • interacting with INTS3 (OBFC2B·INTS3 complex regulates both DNA damage checkpoint activation and DNA damage repair)
  • is uniquely capable of promoting interaction of EXO1 with double-strand DNA ends and stimulates its activity independently of the MRN complex
  • may regulate DNA damage checkpoints by positively modulating TP53 and its downstream target CDKN1A
  • FBXL5 interacts with and targets NABP2 for ubiquitination and degradation
  • cell & other
    REGULATION
    Other phosphorylated by ATM kinase in response to DNA double-strand breaks
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    constitutional       loss of function
    leading to increased radiosensitivity, defective checkpoint activation and enhanced genomic instability coupled with a diminished capacity for DNA repair
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS
  • loss of Obfc2b in mice results in perinatal lethality characterized by growth delay and skeletal abnormalities
  • germline Ssb1(-/-) embryos die at birth from respiratory failure due to severe rib cage malformation and impaired alveolar development, coupled with additional skeletal defects