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FLASH GENE
Symbol UVSSA contributors: mct - updated : 01-09-2015
HGNC name UV-stimulated scaffold protein A
HGNC id 29304
DNA
TYPE functioning gene
STRUCTURE 42.40 kb     14 Exon(s)
MAPPING cloned Y linked N status provisional
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
14 - 4665 - 709 - 2013 23760561
EXPRESSION
Type
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Endocrineneuroendocrinepituitary   
Lymphoid/Immunethymus    
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
HOMOLOGY
Homologene
FAMILY
CATEGORY DNA associated
SUBCELLULAR LOCALIZATION     intracellular
intracellular,nucleus,chromatin/chromosome
basic FUNCTION
  • is an important player in TCR but also lead to a better understanding of the molecular mechanism underlying UV(s)S syndrome
  • forms a complex with USP7, stabilizes ERCC6 and restores the hypophosphorylated form of RNA polymerase II after UV irradiation
  • UVSSA, together with USP7, is implicated in regulating
  • Transcription-coupled nucleotide excision repair (TC-NER) activity
    CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • UVSSA is an evolutionarily conserved protein that participates in Transcription-coupled repair (TCR)through its interaction with ERCC8 and the TFIIH complex
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) UVSS3
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS