basic FUNCTION
| having a role in RN7SK-mediated regulation of transcription |
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negative transcriptional regulator of polymerase II genes, acting by means of the RN7SK system |
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regulates CCNT1 function during cell differentiation, development and cancer progression |
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MEPCE and LARP7 act cooperatively to stabilize 7SK and maintain the integrity of 7SK snRNP |
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LARP7 suppresses CCNT1 activity to inhibit breast cancer progression and metastasis |
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MEPCE and LARP7, participates in the regulation of the transcription elongation by RNA-polymerase II in higher eukaryotes |
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is required for telomerase activity |
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LARP7 family is a conserved factor in telomere maintenance |