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FLASH GENE
Symbol LARP7 contributors: mct - updated : 18-06-2018
HGNC name La ribonucleoprotein domain family, member 7
HGNC id 24912
DNA
TYPE functioning gene
STRUCTURE 20.63 kb     13 Exon(s)
MAPPING cloned Y linked N status provisional
RNA
TRANSCRIPTS type messenger
text two transcripts encode the same protein
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
15 - 2500 - 589 - 2015 25863285
13 - 2303 66.9 582 - 2015 25863285
13 - 2175 66.9 582 - 2015 25863285
EXPRESSION
Type ubiquitous
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Digestiveliver   highly
Endocrineneuroendocrinepituitary  highly
Urinarykidney   highly
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Blood / hematopoieticbone marrow  highly
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • LARP7 N-terminal La module binds and protects the 3' end from degradation
  • C-terminal domain (CTD), is essential for 7SK RNA stability and assembly with CCNT1, and contains an xRRM, a class of atypical RRM first identified in the Tetrahymena thermophila telomerase , that binds to the 3&
  • 900; stem loop of 7SK and inhibits the methyltransferase activity of MEPCE through a C-terminal MEPCE interaction domain (MID)
    HOMOLOGY
    interspecies homolog to Drosophila Mxc
    Homologene
    FAMILY
  • LARP family
  • CATEGORY chaperone/stress , transcription factor
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,cytosolic
    intracellular,nucleus,nucleoplasm,nuclear bodies
    basic FUNCTION
  • having a role in RN7SK-mediated regulation of transcription
  • negative transcriptional regulator of polymerase II genes, acting by means of the RN7SK system
  • regulates CCNT1 function during cell differentiation, development and cancer progression
  • MEPCE and LARP7 act cooperatively to stabilize 7SK and maintain the integrity of 7SK snRNP
  • LARP7 suppresses CCNT1 activity to inhibit breast cancer progression and metastasis
  • MEPCE and LARP7, participates in the regulation of the transcription elongation by RNA-polymerase II in higher eukaryotes
  • is required for telomerase activity
  • LARP7 family is a conserved factor in telomere maintenance
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • is a constitutive component of the 7SK snRNP and localizes to the 3' terminus of the 7SK long noncoding RNA
  • CCNT1 is stored in the 7SK ribonucleoprotein (RNP) that contains the three nuclear proteins HEXIM1, LARP7, and MEPCE
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • binds and stabilizes nearly all the nuclear 7SK via 3' -UUU-OH, leading to the sequestration and inactivation of CCNT1
  • LARP7 interacts with a poly(A) polymerase TUT1 to maintain LIN28A mRNA stability
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) ALAZS
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS