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FLASH GENE
Symbol REG3A contributors: mct - updated : 16-12-2013
HGNC name regenerating islet-derived 3 alpha
HGNC id 8601
DNA
TYPE functioning gene
STRUCTURE 2.75 kb     5 Exon(s)
regulatory sequence Promoter (CAAT box) (TATA box)
Binding site   transcription factor
text structure
  • stimulus-responsive DNA elements
  • regulators of INGAP expression include the transcription factors PDX-1, NeuroD, PAN-1, STAT and AP-1
  • MAPPING cloned Y linked N status confirmed
    Map see REG3G
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    6 - 807 - 175 - 2006 16963458
    5 - 1117 - 175 - 2006 16963458
    6 - 830 - 175 - 2006 16963458
    EXPRESSION
    Type restricted
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestiveintestine    
     stomach    
    Endocrinepancreas   highly Mus musculusAdult
    Urinarybladder    
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Epithelialsecretoryglandular   Mus musculus
    cells
    SystemCellPubmedSpeciesStageRna symbol
    Digestiveacinar Mus musculusAdult
    Endocrineislet cell (alpha,beta...) Mus musculus
    cell lineage
    cell lines
    fluid/secretion secretory pancreatic protein
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
    one c-type lectin family domain
    HOMOLOGY
    Homologene
    FAMILY Reg-related family
    CATEGORY secretory
    SUBCELLULAR LOCALIZATION extracellular
        intracellular
    intracellular,cytoplasm
    basic FUNCTION
  • may be a stress protein involved in the control of bacterial proliferation
  • inducing new pancreatic islets development
  • stimulates beta-cell replication, by activating Akt kinase and increasing the levels of CCND1/CDK4
  • secreted intestinal antimicrobial protein, can promote skin keratinocyte proliferation
  • may potentially mediate the epidermal hyperproliferation observed in normal wound repair and in psoriasis
  • downstream mediator of IL17A that enhances keratinocyte proliferation and downmodulates keratinocyte differentiation
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • PDX-1 binds directly to the INGAP promoter (in a possible feedback loop to block unbridled pancreatic islet expansion)
  • phosphorylated in response to extracellular stimuli by action of MAP3K1
  • cell & other
    REGULATION
    induced by interleukin-17 (IL17) via activation of keratinocyte-encoded IL17 receptor A (IL-17RA)
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    constitutional     --over  
    in ulcerative colitis and Crohn's disease,in primary liver cancerin acute or chronic pancreatitis
    tumoral     --low  
    in gastric cancer
    constitutional     --over  
    in keratinocytes during psoriasis and wound repair
    Susceptibility
    Variant & Polymorphism
    Candidate gene for the treatment of diabetes
    Marker
    Therapy target
    SystemTypeDisorderPubmed
    diabetetype 1 
    can serve as novel targets in diabetes mellitus genetic therapy
    ANIMAL & CELL MODELS