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FLASH GENE
Symbol UNC45A contributors: mct - updated : 10-04-2018
HGNC name unc-45 homolog A (C. elegans)
HGNC id 30594
DNA
TYPE functioning gene
STRUCTURE 23.91 kb     23 Exon(s)
MAPPING cloned Y linked N status provisional
RNA
TRANSCRIPTS type messenger
text
  • is alternatively expressed at the mRNA and protein levels as two isoforms (PMID: 21802425)
  • identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    20 - 3799 - 799 - 2011 Differential
    20 - 3651 - 944 - 2011 Differential
    23 - 4035 - 929 - 2011 Differential
    21 - 3251 - 944 - 2011 Differential
    20 - 3606 - 929 - 2011 Differential
    EXPRESSION
    Type ubiquitous
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestivemouthtongue  highly
    Reproductivefemale systemovary  highly
     male systemtestis  highly
    Respiratorylung   highly
     respiratory tracttrachea  highly
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • N-terminal tetratricopeptide repeat (TRP) domain (&
  • 8764;115 amino acids), paticipating in protein-protein interactions, especially with Hsp70 (HSPA1A) and Hsp90 HSP90AA1, and contributes to the assembly of functional stress fibers
  • a central domain of &
  • 8764;400 amino acids,
  • a C-terminal UCS domain (&
  • 8764;400 amino acids), critical for myosin binding, and the UNC-45/Cro1/She4p domain of UNC-45a is critical for NM-II folding, whereas the N-terminal tetratricopeptide repeat domain
    HOMOLOGY
    interspecies ortholog to C. elegans Unc-45
    Homologene
    FAMILY UCS protein family (UNC-45/CRO1/She4p)
    CATEGORY regulatory
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,Golgi
    intracellular,cytoplasm,cytosolic
    intracellular,cytoplasm,cytoskeleton,microtubule,centrosome
    intracellular,nucleus,nucleoplasm,nuclear bodies,nuclear speckles
    text
  • is also a novel centrosomal protein
  • basic FUNCTION
  • modulator of progesterone receptor chaperoning by HSP90A1
  • regulator for the progesterone receptor/HSP90A1 chaperoning pathway
  • may play a role in erythropoiesis in stroma cells
  • in the spleen
  • involved in cytoskeletal functions, such as cell division or exocytosis
  • molecular chaperone targeted to non-muscle myosins and is essential for cell division
  • centrosomal function for UNC45A and role in cell proliferation and tumorigenesis
  • is likely a crucial component in regulating human NK cell cytoskeletal dynamics via promoting the formation of actomyosin complexes
  • is dispensable for neuron survival but required for neurite elongation
  • is a novel and master regulator of NMII-mediated cellular processes in neurons
  • is a dynamic component of actin stress fibers and functions as a myosin chaperone
  • promotes generation of contractile actomyosin bundles through synchronized nonmuscle myosin II (NM-II) folding and filament-assembly activities
  • plays likely a role in the development of a functional intestinal system
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • binds to the ATP-binding domain of HSP90A1 to prevent the activation of its ATPase activity by the cochaperone AHSA1
  • is required for the normal cellular distribution of HSP90AB1, but not HSP90AA1
  • UNC45A also inhibits signaling through the retinoic acid receptor alpha
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) CCDHB
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --over  
    in breast carcinomas and cell lines derived from breast carcinoma metastases
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS