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FLASH GENE

Symbol

SAP30L

contributors: mct - updated : 27-08-2012

HGNC name	SAP30-like
HGNC id	25663

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

DNA

TYPE	functioning gene
STRUCTURE	15.10 kb     4 Exon(s)

MAPPING

cloned

Y

linked

N

status

provisional

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed NM_024632 4 - 6243 NP_078908 - 183 - 2008 18070604 also called variant 1 NM_001131062 3 - 6120 NP_001124534 - 142 - 2008 18070604 also called variant 2 or delta EX2 exons 1-3-4 evinced a slightly reduced transcriptional repression activity compared to wt SAP30L NM_001131063 3 - 6105 NP_001124535 - 137 - 2008 18070604 also called variant 3 or delta EX2 delta5 exons 1-3-4 lacks a further five amino acids, had almost five times less repression activity compared to wt SAP30L variant 4 - - - isoform 4 - - - 2008 18070604 also called Ldelta EX3,4 exons 1-2 located partly in the cytoplasm and the nucleus but not in the nucleolus unable to associate with SIN3A

EXPRESSION

Type

widely

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Lymphoid/Immune lymph node       highly Reproductive female system ovary     highly

cell lineage

cell lines

fluid/secretion

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains

HOMOLOGY

intraspecies

homolog to SIN3A (70p100)

Homologene

FAMILY

SAP30 family

CATEGORY

transcription factor

SUBCELLULAR LOCALIZATION	intracellular
	intracellular,nucleus,nucleoplasm,nuclear bodies
	intracellular,nucleus,nucleolus

basic FUNCTION	might have a role in recruiting the Sin3-histone deacetylase complex to specific corepressor complexes in response to TGF-beta, leading to the silencing of proliferation-driving genes in the differentiating intestinal epithelial cells
	inducing transcriptional repression, possibly via recruitment of Sin3A and histone deacetylases
	SAP30L and SAP30 play active roles in recruitment of deacetylating enzymes to nucleosomes, and mediate key protein-protein and protein-DNA interaction

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

a component

INTERACTION

DNA

RNA

small molecule

protein	interacts with several components of the Sin3A corepressor complex
	interacting with SAP30 (are able to target Sin3A to the nucleolus)
	associates with the core members of the SIN3A corepressor complex and is able to induce transcriptional repression presumably through SIN3A and class I HDACs

cell & other

REGULATION

ASSOCIATED DISORDERS

ANIMAL & CELL MODELS