basic FUNCTION
| may function as a lipopolysaccharide (LPS)-inducible negative regulator in innate immunity |
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may be involved in endotoxin tolerance |
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a new negative feedback regulator of TLR signaling |
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suppress Toll-like receptor 4-mediated NF-kappaB activation by binding to TRAF6 (Sanada 2008) |
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in addition to playing a negative regulatory role in the TLR4 signaling pathway, negatively regulates the RARRES3-like helicase signaling pathway at the level of MAVS/TRAF6 and MAVS/TRAF3 complexes (Sanada 2008) |
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may play a role in the resistance of cancer cells to oncotherapeutics designed to trigger programmed cell death via protein-protein interactions (Sauve 2008) |