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FLASH GENE
Symbol TRAFD1 contributors: mct/npt - updated : 09-06-2010
HGNC name TRAF-type zinc finger domain containing 1
HGNC id 24808
DNA
TYPE functioning gene
STRUCTURE 28.06 kb     12 Exon(s)
MAPPING cloned Y linked N status provisional
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
12 - 3196 - 582 - Mashima (2005)
12 - 2665 - 582 - Mashima (2005)
EXPRESSION
Type ubiquitous
constitutive of
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Digestivepharynx   highly
Lymphoid/Immunespleen   highly
 tonsils   highly
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • a TRAF6-related zinc finger motif
  • TRAF family member-associated NF-kappaB activator-related sequences
  • HOMOLOGY
    Homologene
    FAMILY
  • TRAF family
  • CATEGORY regulatory
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,mitochondria
    basic FUNCTION
  • may function as a lipopolysaccharide (LPS)-inducible negative regulator in innate immunity
  • may be involved in endotoxin tolerance
  • a new negative feedback regulator of TLR signaling
  • suppress Toll-like receptor 4-mediated NF-kappaB activation by binding to TRAF6 (Sanada 2008)
  • in addition to playing a negative regulatory role in the TLR4 signaling pathway, negatively regulates the RARRES3-like helicase signaling pathway at the level of MAVS/TRAF6 and MAVS/TRAF3 complexes (Sanada 2008)
  • may play a role in the resistance of cancer cells to oncotherapeutics designed to trigger programmed cell death via protein-protein interactions (Sauve 2008)
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule metal binding,
  • Zn2+
  • protein
  • could interact with TICAM1, MAVS, TRAF3, and TRAF6 (Sanada 2008)
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS