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FLASH GENE

Symbol

NIBAN2

contributors: mct - updated : 13-04-2021

HGNC name	niban apoptosis regulator 2
HGNC id	25282

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

DNA

TYPE	functioning gene
STRUCTURE	73.65 kb     14 Exon(s)

MAPPING

cloned

Y

linked

N

status

provisional

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed NM_022833 14 - 4007 NP_073744 83 746 - 2005 16083285 NM_001035534 14 - 3818 NP_001030611 82 733 - 2005 16083285

EXPRESSION

Type

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Digestive salivary gland       highly Reproductive female system placenta         female system uterus cervix       male system prostate       Respiratory lung         Skin/Tegument skin         Homo sapiens

tissue

System Tissue Tissue level 1 Tissue level 2 Level Pubmed Species Stage Rna symbol Connective bone     highly

cells

System Cell Pubmed Species Stage Rna symbol Skin/Tegument keratinocyte Homo sapiens

cell lineage

cell lines

fluid/secretion

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains	a PH or pleckstrin homology domain found near the N-terminus of the polypeptide (AAs 69–192)
	near the C terminus is a region rich in proline phosphorylated at six serine residues (AAs 628–730))

HOMOLOGY

interspecies

ortholog to murine 9130404D14Rik

Homologene

FAMILY

Niban family, FAM129 protein family

CATEGORY

protooncogene

SUBCELLULAR LOCALIZATION	plasma membrane,junction,adherens
	intracellular
	intracellular,cytoplasm,cytosolic
	intracellular,nucleus,nucleoplasm
text	can be localized in the cytosol or associated with the cell junctions
	localized in the plasma cell membrane during mitosis

basic FUNCTION	plays a critical role in cancer cell invasion
	implicated in cell invasion in human melanoma cells in a process controlled by the Erk1/2 signaling cascade
	one crucial facet of the mechanism by which FAM129B promotes cancer cell invasion is likely to be the suppression of apoptosis
	expression of NIBAN2 in epidermal keratinocytes accompanied by alteration of wound healing-related gene expression is likely necessary for regulation of cell motility and thereby, contributes to the appropriate wound healing process
	role for FAM129B in linking WNT/CTNNB1 signaling to apoptosis in melanoma
	is involved in key signaling pathways regulating cell survival, proliferation and apoptosis and found upregulated in many types of cancer promoting invasion

CELLULAR PROCESS	cell life, antiapoptosis

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

a component

normal component of the adherens junction

INTERACTION

DNA

RNA

small molecule

protein	target of the MAP kinase (Erk1/2) signaling cascade in human melanoma cells
	NIBAN2 phosphorylation increased the interaction between NIBAN2 and RAS, resulting in reduced binding of RASA1 to RAS
	NIBAN2 induces NFE2L2 by competing for Kelch-like ECH-associated protein 1 (KEAP1) binding (the negative regulator of NFE2L2) via an ETGE motif
	phosphorylation of NIBAN2 plays a significant role in driving the metastatic potential of BRAF V600E melanoma via upregulation of the NFE2L2 signaling pathway

cell & other

REGULATION

Other

rapid cleavage of FAM129B and cadherin that occurred during apoptosis may be a mechanism that ensures that the antiapoptotic function

ASSOCIATED DISORDERS

corresponding disease(s)

Susceptibility

Variant & Polymorphism

Candidate gene
Marker
Therapy target
	System Type Disorder Pubmed cancer     is a potential therapeutic target

ANIMAL & CELL MODELS