SUBCELLULAR LOCALIZATION
| intracellular
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| intracellular,cytoplasm,organelle,membrane
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| intracellular,cytoplasm,organelle,Golgi
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| intracellular,cytoplasm,organelle,lysosome
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| intracellular,cytoplasm,cytosolic,vesicle
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text
| membrane in the steady state, cytoplasmic face of coated vesicles |
basic FUNCTION
| adaptin beta 1,large chain, transporting ligand-receptor complexes from plasma membrane or Golgi to lysosomes |
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may be also involved in protein sorting to the basolateral plasma membrane of polarized epithelial cells |
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is crucial for correct delivery of many transmembrane proteins from recycling endosomes to the basolateral plasma membrane |
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VAMP3 and AP1B1 cooperate in basolateral membrane trafficking |
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differential expression of AP1B contributes to normal kidney function and illustrates possible roles of this adapter protein in kidney development, physiology, and pathology |
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AP1B1-mediated protein sorting machinery is required for maintenance of immune homeostasis and prevention of excessive inflammation |
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is likely essential for maintaining integrity and ion homeostasis in hair cells |