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FLASH GENE
Symbol HRH1 contributors: mct - updated : 23-12-2011
HGNC name histamine receptor H1
HGNC id 5182
DNA
TYPE functioning gene
STRUCTURE 126.16 kb     3 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked   status confirmed
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
3 - 4427 - 487 - 2011 21697825
  • isoform H/I/K
  • 2 - 4348 - 487 - 2011 21697825
  • isoform F/K
  • 2 - 4298 - 487 - 2011 21697825
  • isoform B/K
  • 2 - 4578 - 487 - 2011 21697825
  • isoform A/K
  • EXPRESSION
    Type widely
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestiveesophagus   highly
     salivary gland   highly Homo sapiens
    Nervousnerve   highly
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
    HOMOLOGY
    Homologene
    FAMILY G protein coupled receptor superfamily
    CATEGORY receptor G
    SUBCELLULAR LOCALIZATION     plasma membrane
        intracellular
    intracellular,cytoplasm
    intracellular,nucleus
    basic FUNCTION
  • activating adenylate cyclase
  • stimulating contraction on smooth muscle in the gut and bronchs and decreasing blood pressure
  • induces cytosolic calcium increase and aquaporin translocation in salivary gland cells
  • endothelial HRH1 expression reduces blood-brain barrier permeability, suggesting that endothelial HRH1 signaling may be important in the maintenance of cerebrovascular integrity
  • histamine signaling through the HRH1 ondendritic cells is an important early event conditioning the quality of the skin effector immune response
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule nucleotide,
    protein
    cell & other
    REGULATION
    activated by CHRM3
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    constitutional     --over  
    in patients with allergic rhinitis
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS