Selected-GenAtlas references SOURCE GeneCards NCBI Gene Swiss-Prot Orphanet Ensembl
HGNC UniGene Nucleotide OMIM UCSC
Home Page
FLASH GENE
Symbol ZNF750 contributors: mct - updated : 11-12-2009
HGNC name zinc finger protein 750
HGNC id 25843
DNA
TYPE functioning gene
STRUCTURE 10.62 kb     3 Exon(s)
regulatory sequence
MAPPING cloned Y linked N status provisional
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
3 - 3218 - 723 - -
EXPRESSION
Type widely
constitutive of
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Digestivemouthtongue  highly
 pharynx   highly
Endocrinethyroid   highly
Lymphoid/Immunethymus    
Respiratoryrespiratory tracttrachea  highly
cells
SystemCellPubmedSpeciesStageRna symbol
Skin/Tegumentkeratinocyte
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
HOMOLOGY
Homologene
FAMILY
  • zinc finger protein family
  • CATEGORY immunity/defense , transcription factor
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,nucleus
    basic FUNCTION
  • involved in direct modulation of the immune system
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule metal binding,
  • zinc ion binding
  • protein
  • direct target of TP63 (TP63-bound and -regulated gene whose induction during epidermal differentiation is inhibited by AEC TP63 mutants)
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) SLDP
    Susceptibility to psoriasis [overlapping the locus for psoriasis susceptibility-2 (PSORS2)]
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    SystemTypeDisorderPubmed
    dermatologyskin 
    potential therapeutic efforts to upregulate epidermal ZNF750 in AEC
    ANIMAL & CELL MODELS