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FLASH GENE
Symbol TARP contributors: mct/npt - updated : 02-11-2022
DNA
TYPE functioning gene
STRUCTURE 14.00 kb     4 Exon(s)
MAPPING cloned Y linked N status confirmed
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
4 - 1027 7 58 - 2012 23019373
  • using the upstream ORF
  • localized to the outer mitochondrial membrane
  • including 5 leucines in heptad repeats followed by a basic region
  • 4 exons
  • 4 - 1027 12 111 - 2012 23019373
  • using the downstream ORF
  • similar to but shorter than TRG@ proteins
  • 4 exons
  • EXPRESSION
    Type widely
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Lymphoid/Immunespleen   highly
     thymus   moderately
    Nervousnerve   highly
    Reproductivemale systemprostate  predominantly
    cell lineage
    cell lines
    fluid/secretion blood
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    HOMOLOGY
    Homologene
    FAMILY
    CATEGORY regulatory
    SUBCELLULAR LOCALIZATION
    basic FUNCTION
  • may playing a role in regulating growth and gene expression in prostate cancer cells
  • play an important role in anti-tumor/microbe immune responses
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    induced by testosterone
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --over  
    in salivary adenoid cystic carcinoma (SACC), and TARP overexpression promoted the growth, migration, and invasion of SACC cells
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
  • may be used as a marker to indicate the development and progression of SACC
  • Therapy target
    SystemTypeDisorderPubmed
    cancer  
    potential utility as a therapeutic target, and for development of immunotherapeutic targeting strategies
    cancerhemopathy 
    is a relevant target for immunotherapeutic T-cell therapy in AML
    ANIMAL & CELL MODELS