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FLASH GENE
Symbol LETMD1 contributors: mct - updated : 19-03-2007
HGNC name LETM1 domain containing 1
HGNC id 24241
DNA
TYPE functioning gene
STRUCTURE 12.00 kb     10 Exon(s)
regulatory sequence Promoter (CAAT box) (TATA box)
text structure
  • promoter region contain several putative binding sites for homeodomain proteins
  • putative TATA box and CAAT box at positions -182 to -177 and -75 to -71, respectively
  • MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    - splicing 2133 41 360 - -
  • transcript containing 9 exons
  • longest product
  • - splicing 2026 35 304 - -
  • transcript containing 9 exons
  • lacking a segment of the 5' exon 1
  • start codon in exon 2
  • - splicing 1645 17 155 - -
  • transcript containing 5 exons
  • lacking of exons 3, 4, 5 & 6
  • start codon in exon 1
  • stop codon in exon 8
  • exon 9 on 3'UTR
  • - splicing 2017 15 138 - -
  • transcript containing 8 exons
  • lacking of exon 3
  • start codon in exon 1
  • stop codon in exon 5
  • exons 6, 7, 8 & 9 on 3'UTR
  • - splicing 1934 11 99 - -
  • transcript containing 7 exons
  • lacking of exons 3 & 4
  • start codon in exon 1
  • stop codon in exon 5
  • exons 6, 7, 8 & 9 on 3'UTR
  • shortest product
  • EXPRESSION
    Type ubiquitous
    constitutive of
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestiveintestinesmall intestine  moderately
    Endocrineadrenal gland   moderately
     parathyroid   highly
     thyroid   moderately
    Respiratoryrespiratory tracttrachea  moderately
    Urinarykidney   moderately
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Connectiveadipose  moderately
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
    HOMOLOGY
    interspecies homolog to murine Letmd1 (80.00 pc)
    Homologene
    FAMILY
    CATEGORY regulatory , protooncogene
    SUBCELLULAR LOCALIZATION
    basic FUNCTION
  • may be a negative regulator of the p53 tumor suppressor
  • playing a role in developpement of human breast cancer
  • acting as a negative regulator of TP53 and contributes to tumorigenesis of various organs including the colon
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein interacting with REEP5
    cell & other
    REGULATION
    induced by the PI3K/Akt signaling pathway
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --over  
    in colorectal carcinoma
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS