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FLASH GENE
Symbol LARP1B contributors: npt - updated : 10-03-2022
HGNC name La ribonucleoprotein domain family, member 1B
HGNC id 24704
DNA
TYPE functioning gene
STRUCTURE 162.28 kb     20 Exon(s)
MAPPING cloned Y linked N status provisional
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
20 splicing 3979 105 914 - 2012 22327645
  • isoform 1
  • 11 splicing 1819 59 522 - 2012 22327645
  • eleven exons
  • using an alternate splice site in the 3' coding region, reuslting in a frameshift
  • isoform 2 is shorter and has a distinct C-terminus
  • 9 splicing 2718 41 358 - 2012 22327645
  • nine exons
  • using an alternate splice site in the 3' coding region, reuslting in a frmaeshift
  • isoform 3 is shroter and has a distinct C-terminus
  • 10 - 2174 - 335 - 2012 22327645
    17 - 4423 - 634 - 2012 22327645
    EXPRESSION
    Type
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestiveintestinelarge intestinecolon  
     salivary gland   highly
    Endocrineneuroendocrinepituitary  highly
     parathyroid   highly
    Reproductivefemale systembreastmammary gland  
    Urinarykidney    
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
    HOMOLOGY
    Homologene
    FAMILY
  • LARP family
  • CATEGORY RNA associated
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,cytosolic,granule
    intracellular,nucleus
    basic FUNCTION
  • may protect the 3' end of newly synthesized small RNAs
  • The unique LARP1B La-module can function as an autonomous factor to confer poly(A) protection and stabilization to heterologous mRNAs
  • having no major role in beta-cells
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA binding
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    constitutional     --low  
    by hypermethylation in beta-thalassemia
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS