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FLASH GENE
Symbol GRAMD1B contributors: mct - updated : 27-04-2020
HGNC name GRAM domain containing 1B
HGNC id 29214
DNA
TYPE functioning gene
STRUCTURE 269.49 kb     20 Exon(s)
MAPPING cloned N linked N status provisional
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
21 - 7934 85.3 738 - 2018 29934528
20 - 7832 - 761 - 2018 29934528
21 - 7916 - 789 - 2018 29934528
21 - 7844 - 765 - 2018 29934528
21 - 8136 - 833 - 2018 29934528
21 - 7955 - 745 - 2018 29934528
20 - 7654 - 698 - 2018 29934528
20 - 7542 - 694 - 2018 29934528
2 - 1180 - 135 - 2018 29934528
EXPRESSION
Type
   expressed in (based on citations)
organ(s)
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • GRAM domain
  • HOMOLOGY
    Homologene
    FAMILY
  • GRAM domain family of proteins
  • CATEGORY transport
    SUBCELLULAR LOCALIZATION     plasma membrane
        intracellular
    intracellular,cytoplasm,organelle,membrane
    intracellular,cytoplasm,organelle,endoplasmic reticulum
    basic FUNCTION
  • GRAMD1B is a key signaling molecule that functions to inhibit cell migration in breast cancer by negating both JAK/STAT and AKT1 signaling
  • responsible for chemo-resistance of the ovarian cancer patients
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
  • novel component of the JAK/STAT signaling pathway
  • a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • role for NPC1 in tethering ER-endocytic organelle Membrane contact sites (MCS) where it interacts with the ER-localised sterol transport protein GRAMD1B to regulate cholesterol egress
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --other  
    GRAMD1B expression levels were also found to be significantly associated with clinicopathological features of the gastric cancer patients, particularly the tumor grades and lymph node status
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
  • novel biomarker in breast cancer
  • Therapy target
    ANIMAL & CELL MODELS