basic FUNCTION
| acting as a transcriptional repressor |
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antagonizing MYC transcriptional activity through interaction with the N-COR/SIN3/HDAC corepressor complex (by the recruitment of opposing chromatin remodeling activities compared to Myc) |
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inhibiting apoptosis via downregulation of PTEN expression |
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interacts with NEK2 at the kinetochore and possibly functions as a novel integrator of spindle checkpoint signaling |
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key role for the MYC-MAX-MXD1 network in the development and progression of neural crest tumors |