basic FUNCTION
| having a dual-specificity phosphatase domain that can dephosphorylate itself |
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may act as an oncogene in anaplastic thyroid cancer, and might be a useful diagnostic marker and therapeutic target of this disease |
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formed a physical complex with MAPK14, and promoted survival of anaplastic thyroid cancer cells by inhibiting MAPK14-mediated apoptosis (Yu 2007) |
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may be be involved in critical signaling events such as control of MAP kinases (Takagaki 2007) |
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Intracellular transport and cell –cell adhesion |
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dephosphorylates the Kap3 subunit of the KIF3 motor and |
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enhances N-cadherin-mediated cell–cell interactions |
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may have a tumor-suppressive function in brain tumors |