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FLASH GENE
Symbol LAMB2 contributors: mct - updated : 26-02-2011
HGNC name laminin, beta 2 (laminin S)
HGNC id 6487
DNA
TYPE functioning gene
STRUCTURE 12.05 kb     32 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked N status confirmed
Map pter - D3S4594 - LAMB2L - LAMB2 - QARS - DAG1 - cen
Authors Durkin (99)
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
32 - 5817 - 1798 - -
EXPRESSION
Type widely
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Digestiveliver   lowly
Endocrinethyroid   moderately
Lymphoid/Immunespleen   moderately
Nervousnervecranial nerve  highly
 spinal cord   moderately
Reproductivefemale systemuterus  highly
Respiratorylung   moderately
 respiratory tracttrachea  moderately
Urinarykidneynephronrenal capsuleglomerulushighly
Visualeye   highly
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Connectiveadipose  highly
Connectivebone  highly
Lymphoid    
Membranebasement   
Muscularsmoothciliary muscle  
Muscularsmoothiris  
Muscularstriatumskeletal  
Nervouscentral   
cell lineage
cell lines
fluid/secretion
at STAGE
physiological period embryo
Text embryonic tissue at a moderately level
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • 4 laminin A/neurexin/sex hormone-binding (LNS) globular domains separated by
  • 13 EGF-like motifs within the N terminal short arm allowing the self assembly of chains through interactions of the most terminal globular domain (VI)
  • a long arm composed of heptad repeats typical of an cell alpha helical coiled-coil protein
  • C-terminal region of beta chains is involved in laminin recognition by integrins and modulates the binding affinities of laminins toward X2-type integrins
  • conjugated GlycoP
    mono polymer heteromer , trimer
    HOMOLOGY
    interspecies homolog to rattus Lamb2 (88.04 pc)
    homolog to murine Lamb2 (88.42 pc)
    intraspecies homolog to LAMB1
    Homologene
    FAMILY
  • laminin family
  • CATEGORY adhesion , structural protein
    SUBCELLULAR LOCALIZATION extracellular
    text glomeruli, nerve fascicle perineurium, vascular, basement membrane of neuromuscular junction (matrix and synaptic cleft of the neuromuscular junction)
    basic FUNCTION
  • mediating the attachment, migration and organization of cells into tissues during embryonic development by interacting with other extracellular matrix components
  • playing a role in anchoring as well as differentiation of podocytes foot processes
  • basement membrane protein laminin beta2, which is incorporated in specific heterotrimeric laminin isoforms
  • essential component of the basement membrane
  • CELLULAR PROCESS cell life, differentiation
    cell migration & motility
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling signal transduction
    a component
  • constituent of basement membrane zone
  • heterotrimerizing with laminin alpha and laminin gamma subunits
  • bÍta subunit of laminin 3, laminin 4, laminin 7, laminin 11, laminin 13 and laminin 15
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • binding directly to voltage-gated calcium channels
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) MCCNS
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS