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FLASH GENE
Symbol CDCA7L contributors: mct - updated : 06-09-2016
HGNC name cell division cycle associated 7-like
HGNC id 30777
DNA
TYPE functioning gene
STRUCTURE 45.03 kb     10 Exon(s)
MAPPING cloned Y linked N status provisional
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
10 - 2922 - 454 - 2014 24634210
9 - 2784 - 408 - 2014 24634210
11 - 2976 - 420 - 2014 24634210
EXPRESSION
Type ubiquitous
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Hearing/Equilibriumear   highly
Lymphoid/Immunethymus   highly
Reproductivemale systemtestis  highly
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Connectiveadipose  highly
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
HOMOLOGY
intraspecies homolog to CDCA7
Homologene
FAMILY
CATEGORY transcription factor
SUBCELLULAR LOCALIZATION     intracellular
intracellular,nucleus,nucleolus
basic FUNCTION
  • potentiating C-Myc transforming activity
  • inhibiting the MAOA promoter and enzymatic activities, and acting as a repressor in apoptotic signaling pathways
  • able to activate the extracellular signal-regulated kinase 1/2 (ERK1/2) signaling pathway and regulate the cell cycle, thus promoting hepatocellular carcinoma (HCC) progression
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    apoptotic signaling pathways
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • MycNTD binding protein, interacting with MYC
  • in the absence of PSIP1, CDCA7L performs chromatin scanning inherent to transcription factors
  • PSIP1 interactions with transcriptional repressor CDCA7L and domesticated transposase POGZ, and the POGZ interaction is nearly identical to the interaction of PSIP1 with KMT2A
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --over  
    in medulloblastoma, with metastatic tumors
    constitutional     --over  
    in hepatocellular carcinoma
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    SystemTypeDisorderPubmed
    cancerdigestiveliver
    may constitute a potential therapeutic target in HCC
    ANIMAL & CELL MODELS