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FLASH GENE
Symbol ALKBH2 contributors: mct - updated : 26-06-2019
HGNC name alkB, alkylation repair homolog 2 (E. coli)
HGNC id 32487
DNA
TYPE functioning gene
STRUCTURE 5.00 kb     4 Exon(s)
MAPPING cloned Y linked N status provisional
RNA
TRANSCRIPTS type messenger
EXPRESSION
Type ubiquitous
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Endocrinethyroid   highly
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Connectiveadipose  highly
Connectivebone  highly
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
HOMOLOGY
interspecies homolog to murine Alkbh2
Homologene
FAMILY alkB family
CATEGORY DNA associated
SUBCELLULAR LOCALIZATION     intracellular
intracellular,nucleus
text strictly nuclear and located in replication foci during S-phase
basic FUNCTION
  • removing 1-methyladenine and 3-methylcytosine from methylated polynucleotides in an alpha-ketoglutarate-dependent reaction, and act by direct damage reversal with the regeneration of the unsubstituted bases
  • co-localize with proliferating cell nuclear antigen (PCNA) in replication foci during S-phase and may have a role in genome maintenance near replication forks
  • ALKBH2-3 and ALKBH7 correct methyl and etheno adducts in DNA
  • CELLULAR PROCESS nucleotide, repair
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS